ABSTRACT: Background: Coronavirus disease (or COVID-19), caused by the novel coronavirus SARS-CoV-2, the most virulent identified to date, remains a major global public health challenge. Given the ...

Atherosclerosis is a lipid-driven chronic inflammatory disease that is modulated by innate and adaptive immunity including humoral immunity. Importantly, antibody alterations achieved by genetic means ...

In this study, investigators evaluated whether a functional C3 gene variant is linked to outcomes after lung transplantation. They focused on the C3R102G polymorphism, which enhances complement ...

Background: Infectious processes are the leading cause of pediatric consultation, and recurrent or severe infections may indicate primary immunodeficiencies (PIDs), which comprise more than 484 rare ...

Some people may already have a tiny bit of protection against H5N1 bird flu. Several recent studies have found that those who caught seasonal flus or received flu vaccinations have low levels of ...

Among people with sickle cell disease—an inherited blood disorder—acute chest syndrome (ACS) is the leading cause of death. The condition is the result of red blood cells becoming stiff, sticky, and ...

In myasthenia gravis, complement plays a big role in what happens to the muscle end of the neuromuscular junction, explains Miriam Freimer, MD, an author on 5 abstracts presented at the recent 15th ...

Expert Rev Clin Immunol. 2008;4(3):379-390. Since there are no genetic deficiencies of CRP in man, animal models have been used to study the role of CRP in inflammatory disease. Two methods have been ...

1 Department of Internal Medicine, Division of Rheumatology, University of New Mexico, Albuquerque, NM 2 Biomedical Research Institute of New Mexico, Albuquerque, NM 3 Department of Molecular Genetics ...

Kawasaki Disease (KD) is an acute febrile systemic vasculitis of unknown etiology and the leading cause of acquired heart disease among children. The complement system is a major component of innate ...