Bleeding because of impaired platelet function is a major side effect of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib. We quantitatively assessed ristocetin-induced platelet aggregation ...

Proteolytic degradation products of fibrinogen, produced as a result of excessive fibrinolysis, have been demonstrated in the blood of cirrhotic patients. 7,8 Such degradation products, when formed in ...

Approximately 40% of adolescent women experience heavy menstrual bleeding (HMB), and 10–62% of them have an underlying bleeding disorder (BD). Diagnosing a BD remains challenging because of ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

Study of the bleeding tendency in uremia in 26 subjects, 10 of whom were bleeding, showed platelet counts and plasma coagulation factors to be normal. There was a significant inverse correlation ...

Researchers have identified serine threonine kinase 10 as a key regulator of platelet function, haemostasis and ...

Patients on prasugrel therapy have greater platelet inhibition than those taking maintenance doses of clopidogrel and thus require a longer time to return to baseline reactivity after stopping the ...

Managing drug dosage is critical to the overall success of pharmaceutical intervention, not only in the clinic but also in clinical trials. Inadequate dose management of certain drugs can have fatal ...

Abstract and Introduction Review of Normal Platelet Physiology and Megakaryocytopoisis Qualitative Platelet Abnormalities Conclusion References Nitric oxide (NO) is another drug used in the neonatal ...

Expert Rev Clin Pharmacol. 2012;5(3):319-336. Aspirin improves clinical outcome in all cardiovascular (CV) syndromes in primary and secondary prevention, including acute events. In high-risk patients, ...

Platelets are expert at patching up leaks in blood vessels, but could they go overboard and seed amyloid-β plaques as well? As reported in Science Signaling on May 24, Aβ monomers bind integrin ...

DUBLIN--(BUSINESS WIRE)--The "Global Platelet Aggregation Devices Market - Segmented by Product (Systems, Reagents, Consumables and Accessories), Application, End User and Geography - Growth, Trends ...