In the fission yeast Schizosaccharomyces pombe, the RNA interference (RNAi) machinery is required to generate small interfering RNAs (siRNAs) that mediate heterochromatic gene silencing. Efficient ...
Many microRNAs (miRNAs) are encoded within the introns of RNA Pol II transcripts, often as polycistronic precursors. Here, we demonstrate the optimization of an intron encoding three endogenous miRNAs ...
Oryza sativa Dicer-like4 Reveals a Key Role for Small Interfering RNA Silencing in Plant Development
MicroRNAs and small interfering RNAs (siRNAs) are two classes of small regulatory RNAs derived from different types of precursors and processed by distinct Dicer or Dicer-like (DCL) proteins. During ...
The distribution of glycans on a monoclonal antibody impacts its function and half-life. Earlier this month, Masue Marbiah, PhD, a postdoctoral researcher at Imperial College London who develops ...
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