Scientists at the University of California, Irvine, have discovered that nuclear speckles, a membraneless organelle within the nucleus, serve as central hubs for pre-mRNA 3′ end processing. This ...

In vitro-transcribed mRNAs have been proven efficient in various therapeutic applications. However, manufacturing them poses challenges due in part to complexity of the molecules as well as the ...

Learn from the MHRA about evolving CMC expectations, submission criteria, and initiatives for streamlining approval routes for mRNA platforms. Continuous processing: Optimizing efficiency & ...

As steadily increasing numbers of mRNA vaccines and therapeutics advance through clinical trials and commercialization, the biopharmaceutical industry is pressed to find ways to make their production ...