An artist’s depiction of an artificially evolved enzyme breaking a silicon-carbon bond. [Caltech/Dow] For the first time, scientists have engineered an enzyme that can break the stubborn man-made ...

Recent trends in directed enzyme evolution focus on combining high-throughput screening methods with advanced biophysical tools and data-driven computational approaches. However, these methods pose ...

A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from ...

Researchers at MIT have made a major breakthrough in optimizing rubisco, a key enzyme in photosynthesis. By modifying a bacterial version of this molecule, they achieved a 25% higher catalytic ...

Using computational design and directed evolution, scientists have successfully created a metalloprotein that can catalyze a commonly used organic reaction more efficiently than any known enzyme (Nat.

Prof Mulholland added: “This sort of analysis could help to design more effective ‘de novo’ enzymes, for reactions that previously we could not target.” The research, published in Nature Chemistry, ...

Enzymes are molecular machines that carry out the chemical reactions that sustain all life, an ability that has captured the ...

Engineered enzymes are poised to have transformative impacts across applications in energy, materials, biotechnology, and medicine. Recently, machine learning has emerged as a useful tool for enzyme ...