Every time our body encounters a new disease-causing agent, a crucial defense system called adaptive immunity comes into play ...
A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...
Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...
The gray portion of this schematic represents a nanodisc, where for the first time researchers were able to replicate the native membrane environment (red dots) of a T-cell receptor (cyan). One of the ...
Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...
This new technique for studying cell receptors could have sweeping implications for drug development
Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...
New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...
A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with fewer off-target effects. Protein complexes that adorn the surface of T cells ...
Blockbuster anti-obesity drugs like Ozempic and Wegovy have become household names in the past few years. They work by activating the glucagon-like peptide 1 receptor (GLP-1R) to stimulate insulin ...
Kanazawa University, in collaboration with Osaka University and the National Institutes for Quantum Science and Technology, ...
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