Heart failure (HF) is one of the leading causes of death and disability worldwide, affecting millions of people and placing an enormous burden on healthcare systems. The disease occurs when the heart ...

Heart failure occurs when the heart can no longer pump blood efficiently to meet the body’s needs. Beyond weakened muscle cells, new research highlights the hidden role of fibroblasts—supporting cells ...

Heart failure is a leading cause of death and disability. Unfortunately, this affects millions of individuals and their loved ones. Ineffective heart function can lead to shortness of breath, fatigue, ...

Jen Davis (left) and Bella Reichardt (right) conducting research in a lab for genetic engineering of heart fibroblasts.at the UW Medicine Institute for Stem Cell and Regeneration Medicine. Fibroblasts ...

The adult mammalian heart bears limited regenerative capacity, resulting in the irreversible loss of cardiomyocytes post-cardiac injury, and often culminating in end-stage heart failure. Cardiomyocyte ...

Cardiovascular disease often culminates in heart failure, a hallmark of which is fibrosis, a form of tissue scarring. Cardiac fibrosis initially repairs damaged heart tissue, but it can quickly become ...

In a recent study published in Nature, researchers investigated the immune-fibroblast communication in human cardiac disease and mouse models. They found that interleukin 1 beta (IL-1β) signaling ...

A recent study has demonstrated what a first-of-its-kind integrated map of heart cells can reveal about cardiac fibrosis. Researchers at the Victor Chang Cardiac Research Institute (Darlinghurst, ...

WASHINGTON (Reuters) - Two studies published on Thursday show new ways to fix damaged hearts, one by turning structural heart cells into beating cells and another by restoring a primordial ability to ...

Researchers have reduced scar formation and improved heart function in mouse models of heart failure using a monoclonal antibody treatment, similar to that approved by the FDA to treat other ...